Surgery for Type 2 Diabetes with Obesity?

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Who would have thought that the most effective available treatment of a metabolic medical disease (that is, type 2 diabetes) could be a surgical solution? A new study in JAMA showed that patients who have type 2 diabetes and who are obese, were far more able to come off their diabetic medications than those who were treated by non-surgical means.

From Melbourne, Australia, an article titled "Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes - A Randomized Controlled Trial" is published in the January 23, 2008 of the Journal of the American Medical Association (JAMA). The aim of the study is to determine if weight loss surgery resulted in better control of type 2 diabetes than medical (non-surgical) approaches to weight loss and diabetes control. Among 55 patients who completed the follow-up (out of 60 patients), remission of type 2 diabetes was achieved by 73% in the surgical group and 13% in the non-surgical group. In this study, the surgical procedure was laparoscopic adjustable gastric banding (Lap Band). Remission meant being able to keep normal diabetic blood tests while not taking diabetes medications anymore. Please notice that the participants' BMI was more than 30 and less than 40. So, the surgeons accepted lower BMI than the usual cut-off of BMI of 35 that is mostly recommended. Furthermore, the study excluded BMI above 40.

This study adds to other pointers from previous research. Dr. Henry Buchwald in his frequently quoted study: "Bariatric Surgery: A Systematic Review and Meta-analysis" reported that weight loss surgery resulted in complete resolution of type 2 diabetes in 76.8% of patients. To my knowledge, not a single conventional non-surgical treatment of diabetes reported anything even close.

Diabetes treated by surgery? Well, this is not a new concept. Actually, in 1992, an article was published under the provocatrive title: "Is type II diabetes mellitus (NIDDM) a surgical disease?". This is one reason why the professional organization for bariatric surgeons in North America changed its name from the "American Society for Bariatric Surgery" (ASBS) to the "American Society for Metabolic and Bariatric Surgery" (ASMBS)

The authors of the reference article, John B. Dixon, MBBS, PhD; Paul E. O’Brien, MD; Julie Playfair, RN; Leon Chapman, MBBS; Linda M. Schachter, MBBS, PhD; Stewart Skinner, MBBS, PhD are from the Centre for Obesity Research and Education (CORE), Monash University, Melbourne, Australia

References:

Dixon JB, O'Brien PE, Playfair J, Chapman L, Schachter LM, Skinner S, Proietto J, Bailey M, Anderson M. Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes: A Randomized Controlled Trial. JAMA. 2008 Jan 23;299(3):316-323 (Abstract)

Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004 Oct 13;292(14):1724-37. PMID: 15479938 (Full Text)

Dixon JB, Pories WJ, O'Brien PE, Schauer PR, Zimmet P.Surgery as an effective early intervention for diabesity: why the reluctance? Diabetes Care. 2005 Feb;28(2):472-4. PMID: 15677819 (Full Text)

Pories WJ, MacDonald KG Jr, Flickinger EG, Dohm GL, Sinha MK, Barakat HA, May HJ, Khazanie P, Swanson MS, Morgan E, et al. Is type II diabetes mellitus (NIDDM) a surgical disease? Ann Surg. 1992 Jun;215(6):633-42; PMID: 1632685 (Full Text)

Abdominal Pain after Gastric Bypass

Let's start with a bottom-line statement: Abdominal pain after gastric bypass (other than the early postoperative recovery) is not normal. You are not expected to have on and off severe pains, nausea or vomiting. Chronic abdominal pain is debilitating and may lead to avoiding eating, and, therefore, unnecessary malnutrition.

Here are some causes of pain after gastric bypass:

1. Bowel obstruction from internal herniation. This condition can be very serious, and may lead to loss of bowel or life. A loop of small bowel glides (herniates) into a defect inside the peritoneal cavity, then becomes trapped. The herniated loop may become strangulated, cutting off the blood supply, which could lead to death of that part of the bowel. I placed this as #1 not because it is common, but because it is probably the most serious and dreaded of all causes of later pain after abdominal surgery.

2. An ulcer, either in the pouch, on the anastomosis, or in the bypassed stomach or duodenum. Ulcers can cause not only severe pain, debilitation and malnutrition, but also may lead to bleeding. An ulcer may even perforate, causing peritonitis. Smoking and chronic intake of non-steroidal anti-inflammatory medications (NSAIDs) are risk factors for the development of ulcers.

3. Gallstones and gallbladder disease.

4. Abdominal wall hernia (incisional hernia, also called ventral hernia) my entrap a loop of bowel causing severe pain. When a hernia does not reduce itself, it is called "incarcerated". An incarcerated hernia may become strangulated, cutting off the blood supply to that loop of intestine. Incisional hernias can occur after any abdominal surgery, and bariatric surgery is no exception.

It is important to not accept pain after gastric bypass surgery as a normal sequence. Make sure that you seek expert help.

Is it really important to do the follow-up visits after bariatric surgery?

After weight loss surgery (let's say gastric bypass or Lap Band), the majority of patients will initially lose some of their excess weight very well. In fact, they may do so well that they take for granted their weight loss trend, and some become less and less compliant with their follow-ups. Does it make a difference? Should patients do their follow-ups with their bariatric surgery programs, in addition to the usual check-ups with their own family doctors? We always felt that patients benefit tremendously from being committed to their long-term follow-ups. Is there any evidecne that long-term follow-ups make any difference? A study is published in the Nov-Dec 2007 issue of the journal "Surgery for Obesity and Related Diseases" titled "Impact of routine and long-term follow-up on weight loss after laparoscopic gastric bypass". It is another addition to a mounting evidence. The authors, (Gould JC, Beverstein G, Reinhardt S, Garren MJ) from the University of Wisconsin School of Medicine, Madison, Wisconsin, looked into the data of patients with 3-4 years of follow-up data after laparoscopic gastric bypass. The patients were divided into 3 groups:

Group 1 patients: had attended every scheduled postoperative appointment
Group 2 patients had attended every appointment for 1 year, then were lost to follow-up
Group 3 patients had been lost to follow-up before 1 year.

Although the excess weight loss (EWL) did not differ at 1 year of follow-up, a significant difference in the EWL was observed at 3-4 years (74% for Group 1; 61% for Group 2; 56% for Group 3). The authors found that the most common explanation for missed follow-up appointments was a lack of insurance coverage. They concluded that on-going, multidisciplinary care is likely a critical component in maintaining the benefit after surgery.


Source Article:
Gould JC, Beverstein G, Reinhardt S, Garren MJ. Impact of routine and long-term follow-up on weight loss after laparoscopic gastric bypass. Surg Obes Relat Dis. 2007 Nov-Dec;3(6):627-30. PMID: 17950045 (Abstract)

Other References:

Shen R, Dugay G, Rajaram K, Cabrera I, Siegel N, Ren CJ. Impact of patient follow-up on weight loss after bariatric surgery. Obes Surg. 2004 Apr;14(4):514-9. PMID: 15130229 (Abstract)

Harper J, Madan AK, Ternovits CA, Tichansky DS. What happens to patients who do not follow-up after bariatric surgery? Am Surg. 2007 Feb;73(2):181-4. PMID: 17305299 (Abstract)

"Surgery for Obesity and Related Diseases" (SOARD) is the official journal of the American Society for Metabolic and Bariatric Surgery (ASMBS) and the Brazilian Society for Bariatric Surgery (SBCBM - Sociedade Brasileira de Cirurgia Bariátrica e Metabólica).

"Obesity surgery" is the official journal of several international societies including, among many others, the International Federation for the Surgery of Obesity (IFSO) , the Obesity Surgery Society of Australia and New Zealand and the French Society for Obesity Surgery (Société Française de Chirurgie de l'Obésité)

Urinary Incontinence & Weight Loss Surgery

We saw some great data about the improvement or resolution of diabetes type 2, hypertension, high cholesterol and sleep apnea after bariatric surgery.

We also read the report about the improvement in fibromyalgia symptoms. Stress urinary continence, however, is not widely talked about. It is the condition in which patients may lose control on their bladder when they sneeze, lift something heavy, laugh or cough. We know that this is common with obesity. Do we have research to back-up the common knowledge that stress urinary incontinence may improve or resolve after bariatric surgery? Well, a recent study from the Weight Management and Metabolic Health Center, University of South Florida, Health Sciences Center, Tampa, Florida by Kurubam et al, that was published in the October 2007 issue of the journal "Surgery for Obesity and Related Diseases"

They, prospectively, collected data from 201 candidates for bariatric surgery. They found that 32% of the patients reported urinary incontinence. Of those 65 patients, 45 underwent bariatric surgery. Of the 38 patients who had complete postoperative follow-up for at least 6 months, 50% enjoyed resolution of urinary incontinence while 37% had reported residual slight-to-moderate incontinence. Residual severe urinary incontinence was reported by 13%. In general, patients reported improvement within 4 months or after losing 50 lb. While the findings of this study are certainly very encouraging, the authors concluded that their findings warrant additional investigation with urodynamic studies.

Reference:

Kurubam D R, Almahmeed T, Martinez F, Torrella TA, Haines K, Nelson LG, Gallagher SF, Murr MM. Bariatric surgery improves urinary incontinence in morbidly obese individuals. Surg Obes Relat Dis. 2007 Oct 17; [PMID: 17950043]

Video clip of animated bariatric procedures

A very good and easy-to-understand animation of the principles of the Roux-en-Y gastric bypass, the biliopancreatic diversion with duodenal switch procedure and the Lap Band, can be viewed in a video clip on the Mayo Clinic website.

http://www.mayoclinic.com/health/gastric-bypass/MM00703

LAP-BAND and REALIZE in USA

While world-wide, there is at least half a dozen of brands of adjustable gastric bands, the USA market had one brand, the Lap Band (manufactured by Inamed, a subsidiary of Allergan, Santa Barbara, California). (see "Adjustable Gastric Band" in the Glossary)

On Sept. 28, 2007, Ethicon Endo-Surgery, Inc. , Cincinnati, Ohio (an operating company of Johnson & Johnson) announced that the U.S. Food and Drug Administration (FDA) has approved for marketing the REALIZE(TM) Adjustable Gastric Band.

In the multi-center U.S. clinical trial of 276 patients with the REALIZE Band, patients who completed the three-year U.S. clinical trial (n=228) lost an average of 42.8 percent of their excess body weight. Thirty-five percent of patients who completed the three-year trial lost 50
percent or more of excess body weight and 10.5 percent lost 75 percent or more of excess body weight. The most commonly reported adverse events after surgery during the U.S. clinical trial were nausea, vomiting, constipation and gastroesophageal reflux (GERD). According to the report, nine (3.3 percent) patients experienced a serious adverse event that was considered unanticipated and related to the REALIZE Band.

According to the press release, the REALIZE Band, which is marketed under the name "Swedish Adjustable Gastric Band" (SAGB) outside the U.S., has been commercially available outside the U.S. since 1996 and has been used by more than 100,000 patients worldwide.

Source:
http://www.ethiconendo.com/.
http://www.realizeband.com/.

Alcohol after Gastric Bypass

A glass of wine or two. A beer. A little mixed drink. Would that be OK after a gastric bypass? Well, early after the surgery, while the stomach is healing, you really want to avoid the irritant effect of alcohol. You want your pouch to heal well. So, the answer, as far as we know, is "no". But, what about drinking, let's say 6 months, a year, or more after the surgery? A very interesting study confirmed the previous opinion, that is, alcohol levels go higher after gastric bypass than people who had no such surgery. In a study published in the September issue of the journal "Surgery for Obesity and Related Diseases" (SOARD), researchers from Stanford School of Medicine, Stanford, California, concluded that the gastric bypass patients had a greater peak alcohol level and a longer time for the alcohol level to come back down to zero than the individuals who did not have gastric bypass. A particularly interesting finding was that the gastric bypass patients did not feel that alcohol influenced them any more than the no-surgery group. Could that explain why there are reports of post-gastric bypass patients who were cited for driving under the influence (DUI) after a small social alcoholic drink? Maybe. But also remember that there are other complications related to alcohol intake. Liver disease from alcohol is well-known. To develop alcoholic liver disease on top of the known obesity-related liver disease can be particularly dangerous. Alcohol is not good for peptic ulcers, either. Alcohol calories are empty calories, which is not what gastric bypass patients want to ingest. Also alcohol drinking has been linked to vitamin B1 deficiency. Severe vitamin B1 deficiency can lead to serious nerve damage, that is, Wernicke’s encephalopathy. So far, we do not have a perfectly scientific answer to the question: Is it OK to drink, in moderation, if you are not driving, several months or years after gastric bypass? We just do not have the final answer, and prefer to err on the cautious side. Better be safe than sorry.

References:
Klockhoff H, Naslund I, Jones AW. Faster absorption of ethanol and higher peak concentration in women after gastric bypass surgery.Br J Clin Pharmacol. 2002 Dec;54(6):587-91.

Hagedorn JC, Encarnacion B, Brat GA, Morton JM. Does gastric bypass alter alcohol metabolism? SOARD. 2007 Sept;3(5):543-8. (Note: This is the study quoted above)

Gallbladder, stones, sludge, and Gastric Bypass

Formation of gallstones or sludge in the gallbladder is known to increase with obesity and with rapid weight loss. According to one report, at 6 months, gallstones had developed in 36% and gallbladder sludge in additional 13% of patients

But another question is: What percentage of patients will actually develop symptoms or problems from gallstones or sludge after bariatric surgery? Well, reports quote anywhere from 3% to 30%.


There are different ways of dealing with the gallbladder, in relation to gastric bypass, and all of them are acceptable. A new trend in recent reports concluded no need to screen for gallbladder disease, based on the low incidence of patients who will actually have symptoms from gallstones after gastric bypass. Some reports will even not consider it necessary to remove a gallbladder with stones during a gastric bypass, because the majority of those with no symptoms before, will not develop symptoms after gastric bypass.


Many surgeons, however, still routinely order an ultrasound of the gallbladder before a gastric bypass. If abnormal, the gallbladder may be removed the same time of a gastric bypass. Surgical removal of the gallbladder is called "Cholecystectomy". Also, if a patient has symptoms of typical biliary pain, even if the ultrasound appears normal, a cholecystectomy may be considered.


Other surgeons routinely recommend the removal of the gallbladder at the time of a gastric bypass surgery, particularly with the open technique. If it is chosen that the gallbladder not be removed at the time of a gastric bypass, most will wait until symptomatic gallbladder disease develops, at which time the gallbladder would be removed (cholecystectomy). Some surgeons will ask patients to take a medication, Ursodiol (Brand Name: Actigall) to help lowering the chance of developing gallstones. One report documented a decrease in the incidence of development of gallstones from 32%, with no treatment to 2%. As you realize, there is no one unified approach.


The symptoms of gallstones or sludge after gastric bypass are not different from the general. In the most typical form, right upper quadrant pain in the abdomen, radiating to the back. However, there are so many variations of this typical picture.


Doing a cholecystectomy after a patient loses weight may be technically easier than during maximum obesity, and will almost always be covered by insurance companies when performed for symptoms. But, notice that treating gallstones, if they migrate to the common bile duct, is much more challenging after gastric bypass. The reason is that, after gastric bypass, patients can no longer have an endoscopic retrograde cholangiopancreatography (ERCP) performed in the usual manner. ERCP is a procedure performed using an endoscope, and allows the extraction of those migrating stones from the common duct, without a need to do surgical cutting into the abdomen. The procedure becomes much more difficult or impossible because the stomach has been completely divided, so the endoscope can no more be guided in the usual way from the stomach to the duodenum. Alternatives do exist, but none of them is that easy, nor the necessary set-up and expertise may be available. Therefore, after gastric bypass, a bigger operation, that is an open common bile duct exploration may be needed. Although the incidence of this particular challenging situation is low, it is still a significant occurrence for the individual unfortunate patient. This possibility needs also to be factored when deciding, weighing the benefits vs. the risks of removing the gallbladder along with a gastric bypass.

Life Expectancy - again

A very good article reporting and commenting on the 2 studies from the August 23 issue of the New England Journal of Medicine (NEJM), appeared in the Independant Weekly of Lafayette, Louisiana. It is titled "Life Expectancy - New studies show bariatric surgery patients are living longer." By following this Link, you can access the article. This "Bariatrics Lounge" blog reported on the NEJM article on August 22, so our readers were among the first to be informed. You can go back to that blog entry by clicking this Link.

Just to be thinner?

I read a statement like "It's sad what some put themselves (or their kids) through, in order to be thin." Of course, referring to going through bariatric surgeries like Lap Band, gastric bypass, etc. This statement shows a major misconception as to what bariatric surgery is all about. The name "weight loss surgery" is correct in that bariatric surgery is designed to lead to weight loss. That is true. But the above statement implies that the entire reason for the weight loss is for a "thin" image. Here comes the misunderstanding. Although many patients like being thinner, which is a bonus result of the surgery, the real reason to have the surgery is for health purposes. Morbid obesity leads to three categories of major problems: (1) Life expectancy may be shortened (2) Co-morbidities may get worse, and certainly would not be cured (please, see note below) (3) Quality of life may deteriorate. Those are the real reasons why someone should consider bariatric surgery. Patients do not come and say, "I need weight loss surgery because I want to be thinner." They say things like "I want to get my [type 2] diabetes cured", "I want to be able to play with the kids", "I have many in my family who died from heart disease, and I am still young and would like to prevent that", "my orthopedic surgeon wanted me to lose weight before he replaces my bad knees", "I have sleep apnea, and my doctor said if I lose weight, I may be able to come off the CPAP machine." You've got the picture. So, my counterstatement to the first line here would be "It's sad what some put themselves (or their kids) through, by not controlling their weight and allowing an unhealthy life style to continue." And, as an aside, yes, weight loss will also lead to being thinner. Remember, bariatric surgery is not for everyone who has a problem with weight or obesity. In well-selected patients, the risk of bariatric surgery is, statistically, less than the risk of morbid obesity itself. It is an option if non-surgical weight loss fails to achieve a sustained healthy weight.



Note: "Co-morbidities" is the term given to describe medical problems that are either caused by, or made worse by, obesity.

Plastic Surgery after Massive Weight Loss

This posting is in response to a request to comment on cosmetic surgery for excess skin in the abdomen and other places, after weight loss surgery.

Body contouring, body lift, body shaping or body reshaping are alternative terms used to describe a group of plastic surgery procedures performed after massive weight loss, to manage hanging excess skin. Patients have to have reached a stable plateau weight before any such plastic surgery procedures. The person should have lost at least 100 pounds or achieved the target or maximum weight loss, had a stable weight for a good length of time after the weight loss surgery, and be in good health and not planning on becoming pregnant. Good candidates for a body lift should also have no medical problems that prevent them from going under general anesthesia for major surgery, and should not smoke. Smoking decreases blood flow to the tissues and, therefore, may slow healing.

Plastic surgery procedures after weight loss surgery include the following:

1. Panniculectomy: This is excising the "pannus", which is the excess hanging skin that is present below the belly-button.

2. Abdominoplasty (Tummy Tuck): Includes dissection and preservation of the umbilicus itself, and a more extensive skin mobilization and more aggressive skin removal than panniculectomy. A complete abdominoplasty also includes tightening of the abdominal wall muscles. Abdominoplasty and incisional hernia repair can be combined into a single procedure.

3. Arm lift or brachioplasty.

4. Breast lift or mastopexy.

5. Lower body lift is a combination of an abdominoplasty, plus a thigh and buttock lift. It requires a large incision around the belt line to lift the lower body.

6. Liposuction uses small, narrow tubes to remove fat and is often used in combination with other lifting procedures to help achieve better contouring in various parts of the body.

Combining multiple "lifts" entails longer operative time, and more potential blood loss, but is very appealing to many patients, from the stand-point of time off work and out-of-pocket costs. Combined procedures are avoided if there is active smoking history or medical problems that make a longer operation a particularly risky undertaking.

Insurance coverage varies from carrier to carrier, and a carrier may have different plans with different provisions. Almost all insurance carriers specify that coverage of aesthetic (cosmetic) surgery is excluded. Definition of medical necessity, that is essential for coverage, is variable.

Possible complications after body-contouring surgery include seroma (collection of thin serous or serosnaguineous fluid), hematoma (collection of blood), wound separation (usually minor), swelling and scarring. All patients will have scars, and basically the surgery trades excess skin for scars. For a small number of patients, scars can be excessively thick or inflamed. Before going for body contouring surgery, any nutritional deficiencies (as protein malnutrition, anemia, loss of muscle mass, and osteopenia/osteoporsis) need to be addressed and corrected.

Body contouring is considered major surgery. The outcome of body shaping is generally extremely satisfying to patients. It may take several months to see the final results of the procedure.

Bariatric Surgery Lowers Long-Term Mortality

More data to support that bariatric surgery may improve mortality. Two new studies are published in the August 23, 2007 issue of the New England Journal of Medicine, indicating that bariatric surgery resulted in decreased overall mortality, in addition to the known effective long-term weight loss. One study came from Utah (Adams et al.). The other came from Sweden (Sjöström, et al). In an Editorial in the Journal, Dr. George A. Bray of the Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, commented that those articles "may provide the missing link between intentional weight loss and lives saved for obese patients"

The Utah study is a retrospective study that aimed at determining the long-term mortality among more than 9000 patients who had undergone gastric bypass and a comparable number of severely obese persons who applied for driver's licenses. During follow-up averaging 7 years, mortality in the surgery group decreased by 56% for coronary artery disease, by 92% for diabetes, and by 60% for cancer. On the other hand, mortality from accidents and suicide, was 58% higher in the surgery group than in the control group. All in all, there was a survival benefit from bariatric surgery.

The other article titled "Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects" reports a prospective, controlled Swedish Obese Subjects study involving more than 4000 obese subjects. The study reports on the overall mortality during an average of 10.9 years of follow-up with an impressive follow-up rate of 99.9%. The study concluded that bariatric surgery for severe obesity is associated with long-term weight loss and decreased overall mortality.

References:

Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD, Lamonte MJ, Stroup AM, Hunt SC.Long-term mortality after gastric bypass surgery.N Engl J Med. 2007 Aug 23;357(8):753-61. PMID: 17715409 (Full Text)

Sjöström L, Narbro K, Sjöström CD, Karason K, Larsson B, Wedel H, Lystig T, Sullivan M, Bouchard C, Carlsson B, Bengtsson C, Dahlgren S, Gummesson A, Jacobson P, Karlsson J, Lindroos AK, Lönroth H, Näslund I, Olbers T, Stenlöf K, Torgerson J, Agren G, Carlsson LM; Swedish Obese Subjects Study.Effects of bariatric surgery on mortality in Swedish obese subjects.N Engl J Med. 2007 Aug 23;357(8):741-52. PMID: 17715408 (Full Text)

Does fibromyalgia improve after weight loss surgery?

Well, there are not too many studies that specifically address this issue. Of course the medical literature is full of evidence that musculoskeletal painful conditions in weight-bearing joints do improve with weight loss surgery in the vast majority of patients. However, when it comes to non-weight-bearing joints, and to fibromyalgia in particular, such information is scarce.

However, a study from the University Hospitals of Cleveland that was published in January 2007 did, indeed address that issue. (1)

Fibromyalgia syndrome (FMS) is one of the most common musculoskeletal diseases. Patients have fatigue, chronic diffuse musculoskeletal pains, poor sleep, and stiffness. There is no blood test to diagnose fibromyalgia. To make a diagnosis of FMS, widespread pain symptoms must exist for at least 3 months. The diagnosis is confirmed by finding at least 11 of 18 specific areas of point tenderness. Almost 9:1 patients are females.

In the study from Cleveland, FMS decreased by an impressive 90% after bariatric surgery. As for upper extremity pain, that is, of course,non-weight-bearing, 79% of patients had pain before surgery, compared to 40% after bariatric surgery.

References:

(1) Hooper MM, Stellato TA, Hallowell PT, Seitz BA, Moskowitz RW. Musculoskeletal findings in obese subjects before and after weight loss following bariatric surgery. Int J Obes (Lond). 2007 Jan;31(1):114-20.

Pregnancy and Bariatric Surgery

A recent article from the University of Texas at Houston, TX (1), that appeared in the August issue of the Archives of Pediatric and Adolescent Medicine, reported that the mothers of offspring with some important birth defects (including spina bifida and heart defects) are more likely to be obese than mothers of offspring who do not have any of those defects. The authors admitted that the mechanisms are unknown, but a relationship to undiagnosed diabetes was proposed.

Is it good to have low birth weight? The answer is, generally, No. Studies of populations in the United States and Europe have indicated a significant increase in the incidence of certain diseases in adulthood (coronary artery disease, stroke, and type 2 diabetes) among the low birth weight. This is interesting because the same adult diseases have higher incidence with adulthood obesity. So, does low birth weight correlate with obesity later on? A study about a famine in the Netherlands in the 1940s (2) did show that at the age of 19, the offspring of mothers exposed to the famine during the first half of pregnancy did have higher incidence of obesity.

Previous reports concluded that fetal exposure to diabetes in the uterus is an independant risk for the development of diabetes later in life. Pregnancy in patients with morbid obesity may lead to higher incidence of gestational diabetes and hypertension, preeclampsia, large-for-age fetus, preterm labor, and antepartum stillbirth. (3,4)

So, is it good to be pregnant after bariatric surgery? A review article that appeared in May 2007 in the journal "Medical Clinics of North America" (5) concluded that pregnancy after weight loss surgery is safe and has good outcomes. Cesarean deliveries occur more frequently in all of the reports of pregnancies after bariatric surgery when compared with the general population. Interestingly, there is also a higher incidence of cesarean section deliveries with obesity (3)

In general, it is recommended that pregnancy be avoided during the period of maximal weight loss, typically the first 18-24 months after a gastric bypass. When pregnancy does occur, there is a risk of malnutrition and anemia if ntritional supplements are not taken as advised. With that precaution in mind, studies of pregnancy after gastric bypass (6) and Lap Band (7) showed normal and healthy outcomes. A study from Australia (6) reported that pregnancy outcomes after Laparoscpic Adjustable Gastric Band Placement (Lap Band) are consistent with general community outcomes rather than outcomes from severely obese women.

A word of warning. There have been reports of rare incidences of internal herniation causing dangerous bowel obstruction late in pregnancy after laparoscopic gastric bypass. Though rare, such a possibility should be kept in mind if a pregnant develops acute abdominal pain or signs of bowel obstruction late during pregnancy.(8-10)

References:

(1) Waller DK, Shaw GM, Rasmussen SA, Hobbs CA, Canfield MA, Siega-Riz AM, Gallaway MS, Correa A; National Birth Defects Prevention Study. Prepregnancy obesity as a risk factor for structural birth defects. Arch Pediatr Adolesc Med. 2007 Aug;161(8):745-50. PMID: 17679655

(2) Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med. 1976 Aug 12;295(7):349-53. PMID: 934222

(3) Hall LF, Neubert AG. Obesity and pregnancy. Obstet Gynecol Surv. 2005 Apr;60(4):253-60. PMID: 15795633

(4) Cedergren MI. Maternal morbid obesity and the risk of adverse pregnancy outcome. Obstet Gynecol. 2004 Feb;103(2):219-24. PMID: 14754687

(5) Patel JA, Colella JJ, Esaka E, Patel NA, Thomas RL. Improvement in infertility and pregnancy outcomes after weight loss surgery. Med Clin North Am. 2007 May;91(3):515-28, xiii. PMID: 17509393

(6) Dao T, Kuhn J, Ehmer D, Fisher T, McCarty T. Pregnancy outcomes after gastric-bypass surgery. Am J Surg. 2006 Dec; 192(6):762-6. PMID: 17161090

(7) Dixon JB, Dixon ME, O'Brien PE. Birth outcomes in obese women after laparoscopic adjustable gastric banding. Obstet Gynecol. 2005 Nov;106(5 Pt 1):965-72. PMID: 16260513

(8) Ahmed AR, O'Malley W. Internal hernia with Roux loop obstruction during pregnancy after gastric bypass surgery. Obes Surg. 2006 Sep;16(9):1246-8. PMID: 16989713

(9) Baker MT, Kothari SN. Successful surgical treatment of a pregnancy-induced Petersen's hernia after laparoscopic gastric bypass. Surg Obes Relat Dis. 2005 Sep-Oct;1(5):506-8. PMID: 169252793

(10) Charles A, Domingo S, Goldfadden A, Fader J, Lampmann R, Mazzeo R. Small bowel ischemia after Roux-en-Y gastric bypass complicated by pregnancy: a case report. Am Surg. 2005 Mar;71(3):231-4. PMID: 15869139